Zahurul Haque Asna S M, Ashraful Haq J
Department of Microbiology, Chittagong Medical College, Chittagong, Bangladesh.
Int J Antimicrob Agents. 2000 Nov;16(3):249-51. doi: 10.1016/s0924-8579(00)00230-2.
Salmonella typhi is an important cause of enteric fever in Bangladesh. Resistance to commonly used antibiotics like cotrimoxazole and ampicillin has led to the introduction of third generation cephalosporins and fluoroquinolones for the treatment of enteric fever. Prescription patterns for enteric fevers and for other infections have been changing and so we looked at the antibiotic resistance of S. typhi isolated from patients in and around Dhaka City from 1996-1998. The study showed a gradual change in resistance to ampicillin and cotrimoxazole among S. typhi in our area. The rate of resistance to cotrimoxazole, ampicillin and chloramphenicol decreased from 59.6 to 5.6% in S. typhi over a 3 year period. The extensive use of third generation cephalosporins and fluoroquinolones, in place of conventional antibiotics, has probably influenced the change in resistance pattern in S. typhi.
伤寒沙门氏菌是孟加拉国肠热病的一个重要病因。对常用抗生素如复方新诺明和氨苄青霉素产生的耐药性，促使人们引入第三代头孢菌素和氟喹诺酮类药物来治疗肠热病。肠热病和其他感染的处方模式一直在变化，因此我们研究了1996年至1998年从达卡市及其周边地区患者中分离出的伤寒沙门氏菌的抗生素耐药性。研究表明，我们地区伤寒沙门氏菌对氨苄青霉素和复方新诺明的耐药性在逐渐变化。在3年时间里，伤寒沙门氏菌对复方新诺明、氨苄青霉素和氯霉素的耐药率从59.6%降至5.6%。广泛使用第三代头孢菌素和氟喹诺酮类药物替代传统抗生素，可能影响了伤寒沙门氏菌耐药模式的变化。
