Price C T, Lee I R, Gustafson J E
Microbiology and Biochemistry Groups, School of Biomedical Sciences, Curtin University of Technology, Perth 6845, WA, Australia.
Int J Biochem Cell Biol. 2000 Oct;32(10):1029-43. doi: 10.1016/s1357-2725(00)00042-x.
Salicylate and related compounds, such as aspirin, have a variety of effects in eucaryotic systems and are well known for their medicinal properties. Salicylate also has numerous effects on bacteria, yet only a handful of individuals within the scientific community appreciate these findings. From a bacterial viewpoint, growth in the presence of salicylate can be both beneficial and detrimental. On one hand, growth of certain bacteria in the presence of salicylate can induce an intrinsic multiple antibiotic resistance phenotype. On the other hand, growth in the presence of salicylate can reduce the resistance to some antibiotics and affect virulence factor production in some bacteria. This review provides an overview of the effects salicylate has on various bacterial species.
水杨酸盐及相关化合物，如阿司匹林，在真核生物系统中具有多种作用，且因其药用特性而广为人知。水杨酸盐对细菌也有众多影响，但科学界只有少数人了解这些发现。从细菌的角度来看，在水杨酸盐存在的情况下生长可能既有益又有害。一方面，某些细菌在水杨酸盐存在的情况下生长可诱导内在的多重抗生素耐药表型。另一方面，在水杨酸盐存在的情况下生长会降低对某些抗生素的耐药性，并影响某些细菌中毒力因子的产生。本综述概述了水杨酸盐对各种细菌物种的影响。
