Song Yaping, Sun Qiang, Luo Jiangqi, Kong Yueqi, Pan Bolin, Zhao Jing, Wang Yue, Yu Chengzhong
Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD, 4072, Australia.
Centre for Microscopy and Microanalysis, University of Queensland, Brisbane, QLD, 4072, Australia.
Nanomicro Lett. 2022 Mar 29;14(1):83. doi: 10.1007/s40820-022-00826-4.
A ‘dual active templating’ strategy is firstly reported, using cationic and anionic bactericidal agents as co-templates for the preparation of antibacterial silica nanocomposite with spiky nanotopography. The spiky nanocomposite exhibited enhanced antibacterial and biofilm inhibition performance, compared to pure antimicrobial cationic agent templated smooth silica nanocomposite.
Silica-based materials are usually used as delivery systems for antibacterial applications. In rare cases, bactericidal cationic surfactant templated silica composites have been reported as antimicrobial agents. However, their antibacterial efficacy is limited due to limited control in content and structure. Herein, we report a “dual active templating” strategy in the design of nanostructured silica composites with intrinsic antibacterial performance. This strategy uses cationic and anionic structural directing agents as dual templates, both with active antibacterial property. The cationic-anionic dual active templating strategy further contributes to antibacterial nanocomposites with a spiky surface. With controllable release of dual active antibacterial agents, the spiky nanocomposite displays enhanced anti-microbial and anti-biofilm properties toward . These findings pave a new avenue toward the designed synthesis of novel antibacterial nanocomposites with improved performance for diverse antibacterial applications. [Image: see text]
The online version contains supplementary material available at 10.1007/s40820-022-00826-4.
首次报道了一种“双活性模板”策略，使用阳离子和阴离子杀菌剂作为共模板来制备具有尖刺纳米形貌的抗菌二氧化硅纳米复合材料。与纯抗菌阳离子剂模板化的光滑二氧化硅纳米复合材料相比，这种尖刺状纳米复合材料表现出增强的抗菌和生物膜抑制性能。
二氧化硅基材料通常用作抗菌应用的递送系统。在极少数情况下，已报道杀菌阳离子表面活性剂模板化的二氧化硅复合材料可作为抗菌剂。然而，由于其含量和结构的控制有限，它们的抗菌效果受到限制。在此，我们报道了一种在设计具有固有抗菌性能的纳米结构二氧化硅复合材料时的“双活性模板”策略。该策略使用阳离子和阴离子结构导向剂作为双模板，二者均具有活性抗菌性能。阳离子 - 阴离子双活性模板策略进一步促成了具有尖刺表面的抗菌纳米复合材料。随着双活性抗菌剂的可控释放，这种尖刺状纳米复合材料对……显示出增强的抗菌和抗生物膜性能。这些发现为设计合成具有改进性能的新型抗菌纳米复合材料以用于各种抗菌应用开辟了一条新途径。[图：见正文]
在线版本包含可在10.1007/s40820-022-00826-4获取的补充材料。
