Kawahito S, Takano T, Nakata K, Maeda T, Nonaka K, Linneweber J, Schulte-Eistrup S, Sato T, Mikami M, Glueck J, Nosé Y
Baylor College of Medicine, Department of Surgery, Houston, Texas 77030, USA.
Artif Organs. 2000 Oct;24(10):816-20. doi: 10.1046/j.1525-1594.2000.06646.x.
When the rotary blood pump is used as a left ventricular assist device (LVAD), the arterial blood pressure waveform changes with the LVAD condition. Based on evidence from an in vitro study, the change of the arterial blood pressure waveform during left ventricular assistance was evaluated using animal models. After the left pleural cavity was opened through the fifth intercostal space under general anesthesia, a rotary blood pump was implanted as an LVAD into 6 healthy calves. The direct left carotid arterial blood pressure waveform was measured and recorded by an oscilloscope. The Fast Fourier Transform technique was utilized to analyze the arterial blood pressure waveform and calculate the pulsatility index (PI) and the pulse power index (PPI). Similar to the in vitro study, the PI and PPI decreased exponentially with the increase of the LVAD assist ratio. By using this analysis methodology, a physiologically effective ventricular assistance might be achieved.
当旋转血泵用作左心室辅助装置（LVAD）时，动脉血压波形会随LVAD状态而变化。基于一项体外研究的证据，使用动物模型评估了左心室辅助期间动脉血压波形的变化。在全身麻醉下通过第五肋间打开左胸腔后，将旋转血泵作为LVAD植入6头健康小牛体内。用示波器测量并记录左颈总动脉直接血压波形。利用快速傅里叶变换技术分析动脉血压波形并计算搏动指数（PI）和脉搏功率指数（PPI）。与体外研究相似，PI和PPI随LVAD辅助比率的增加呈指数下降。通过使用这种分析方法，可能实现生理上有效的心室辅助。
