霍奇金淋巴瘤与爱泼斯坦-巴尔病毒
Hodgkin's disease and the Epstein-Barr virus.
作者信息
Flavell K J, Murray P G
机构信息
Department of Pathology, Medical School, University of Birmingham, UK.
出版信息
Mol Pathol. 2000 Oct;53(5):262-9. doi: 10.1136/mp.53.5.262.
Abstract
Hodgkin's disease is an unusual cancer because the malignant cells constitute only a minority of the total tumour mass and, as a consequence, the study of these cells has been a major challenge. Recently, the application of newer technologies, such as single cell polymerase chain reaction (PCR) and gene expression array analysis, to the study of Hodgkin's disease have yielded new insights into the pathogenesis of this tumour. In addition, the recognition that a proportion of Hodgkin's disease tumours harbour the Epstein-Barr virus (EBV) and that its genome is monoclonal in these tumours suggests that the virus contributes to the development of Hodgkin's disease in some cases. This review summarises current knowledge of the pathogenesis of Hodgkin's disease with particular emphasis on the association with EBV.
摘要
霍奇金淋巴瘤是一种特殊的癌症，因为恶性细胞仅占肿瘤总体积的一小部分，因此，对这些细胞的研究一直是一项重大挑战。最近，诸如单细胞聚合酶链反应（PCR）和基因表达阵列分析等新技术应用于霍奇金淋巴瘤的研究，为该肿瘤的发病机制带来了新的见解。此外，认识到一部分霍奇金淋巴瘤肿瘤含有爱泼斯坦-巴尔病毒（EBV），并且在这些肿瘤中其基因组是单克隆的，这表明该病毒在某些情况下促成了霍奇金淋巴瘤的发生。本综述总结了霍奇金淋巴瘤发病机制的当前知识，特别强调了与EBV的关联。
相似文献
1
Hodgkin's disease and the Epstein-Barr virus.霍奇金淋巴瘤与爱泼斯坦-巴尔病毒
Mol Pathol. 2000 Oct;53(5):262-9. doi: 10.1136/mp.53.5.262.
2
Infection by Epstein-Barr virus in Hodgkin's disease is not restricted to the Reed-Sternberg cells.
Br J Haematol. 1994 Feb;86(2):405-6. doi: 10.1111/j.1365-2141.1994.tb04753.x.
3
Epstein-Barr virus and Hodgkin's disease: a comparative immunological, in situ hybridization, and polymerase chain reaction study.爱泼斯坦-巴尔病毒与霍奇金病：一项比较性免疫、原位杂交及聚合酶链反应研究
APMIS. 1994 Jul;102(7):495-500. doi: 10.1111/j.1699-0463.1994.tb05196.x.
4
Presence of Epstein-Barr virus and strain type assignment in Argentine childhood Hodgkin's disease.阿根廷儿童霍奇金淋巴瘤中爱泼斯坦-巴尔病毒的存在及毒株类型鉴定
Blood. 1995 Nov 15;86(10):3922-9.
5
The role of Epstein-Barr virus in Hodgkin's disease from different geographical areas.爱泼斯坦-巴尔病毒在不同地理区域霍奇金淋巴瘤中的作用。
Arch Dis Child. 1996 Jan;74(1):27-31. doi: 10.1136/adc.74.1.27.
6
7
AIDS-related lymphoma in Brazil. Histopathology, immunophenotype, and association with Epstein-Barr virus.巴西的艾滋病相关淋巴瘤。组织病理学、免疫表型及与爱泼斯坦-巴尔病毒的关联
Am J Clin Pathol. 1996 Feb;105(2):230-7. doi: 10.1093/ajcp/105.2.230.
8
Hodgkin's disease.
Baillieres Clin Haematol. 1992 Jan;5(1):57-79. doi: 10.1016/s0950-3536(11)80035-1.
9
bcl-2 expression in Hodgkin's disease. Correlation with the t(14;18) translocation and Epstein-Barr virus.霍奇金病中bcl-2的表达。与t(14;18)易位及爱泼斯坦-巴尔病毒的相关性
Am J Clin Pathol. 1993 May;99(5):604-8. doi: 10.1093/ajcp/99.5.604.
10
The role of Epstein-Barr virus in the pathogenesis of Hodgkin's disease.
J Pathol. 1994 Nov;174(3):141-9. doi: 10.1002/path.1711740302.
引用本文的文献
1
Epstein-Barr Virus Latent Membrane Protein 2A (LMP2A) Enhances ATP Production in B Cell Tumors through mTOR and HIF-1α.EB 病毒潜伏膜蛋白 2A（LMP2A）通过 mTOR 和 HIF-1α 增强 B 细胞肿瘤中的 ATP 产生。
Int J Mol Sci. 2024 Apr 2;25(7):3944. doi: 10.3390/ijms25073944.
2
The potential role of the microbiota in prostate cancer pathogenesis and treatment.肠道菌群在前列腺癌发病机制和治疗中的潜在作用。
Nat Rev Urol. 2023 Dec;20(12):706-718. doi: 10.1038/s41585-023-00795-2. Epub 2023 Jul 25.
3
Epstein-Barr Virus-Induced Genes and Endogenous Retroviruses in Immortalized B Cells from Patients with Multiple Sclerosis.EBV 诱导基因和多发性硬化症患者永生 B 细胞中的内源性逆转录病毒。
Cells. 2022 Nov 15;11(22):3619. doi: 10.3390/cells11223619.
4
Association of TLR9-1237T>C; rs5743836 polymorphism with increased risk of Hodgkin's lymphoma: A case-control study.TLR9-1237T>C; rs5743836 多态性与霍奇金淋巴瘤风险增加相关：一项病例对照研究。
PLoS One. 2022 Jul 29;17(7):e0272312. doi: 10.1371/journal.pone.0272312. eCollection 2022.
5
Identification of seasonal variation in the diagnosis of acute myeloid leukaemia: a population-based study.鉴定急性髓系白血病诊断中的季节性变化：一项基于人群的研究。
Br J Haematol. 2022 Aug;198(3):545-555. doi: 10.1111/bjh.18279. Epub 2022 May 31.
6
Epstein-Barr Virus Expression in Classic Hodgkin Lymphoma in an Indian Cohort and its Association with Clinical and Histomorphological Parameters.印度队列中经典型霍奇金淋巴瘤的爱泼斯坦-巴尔病毒表达及其与临床和组织形态学参数的关联
Indian J Hematol Blood Transfus. 2021 Jul;37(3):372-378. doi: 10.1007/s12288-020-01359-9. Epub 2020 Oct 1.
7
Targeting Host Cellular Factors as a Strategy of Therapeutic Intervention for Herpesvirus Infections.靶向宿主细胞因子作为治疗疱疹病毒感染的策略。
Front Cell Infect Microbiol. 2021 Mar 19;11:603309. doi: 10.3389/fcimb.2021.603309. eCollection 2021.
8
CD21 (Complement Receptor 2) Is the Receptor for Epstein-Barr Virus Entry into T Cells.CD21（补体受体 2）是 Epstein-Barr 病毒进入 T 细胞的受体。
J Virol. 2020 May 18;94(11). doi: 10.1128/JVI.00428-20.
9
Targeting trimeric transmembrane domain 5 of oncogenic latent membrane protein 1 using a computationally designed peptide.使用计算机设计的肽靶向致癌潜伏膜蛋白1的三聚体跨膜结构域5。
Chem Sci. 2019 Jun 27;10(32):7584-7590. doi: 10.1039/c9sc02474c. eCollection 2019 Aug 28.
10
Programmed cell death 1 expression and Epstein-Barr virus infection in chronic lymphocytic leukaemia: a prospective cohort study.慢性淋巴细胞白血病中程序性细胞死亡1表达与爱泼斯坦-巴尔病毒感染：一项前瞻性队列研究。
Cancer Manag Res. 2019 Aug 12;11:7605-7618. doi: 10.2147/CMAR.S212069. eCollection 2019.
本文引用的文献
1
Familial Hodgkin's disease: its significance and implications.家族性霍奇金病：其意义及影响
Ann Intern Med. 1959 Nov;51:933-71. doi: 10.7326/0003-4819-51-5-933.
2
Seasonal incidence of clinical onset of Hodgkin's disease.霍奇金病临床发病的季节性发病率。
Br Med J. 1961 Sep 2;2(5252):621-3. doi: 10.1136/bmj.2.5252.621.
3
Studies in Hodgkin's syndrome. XII. Hereditary and epidemiologic espects.
Ann Intern Med. 1957 Aug;47(2):300-16. doi: 10.7326/0003-4819-47-2-300.
4
Expression of the tumour necrosis factor receptor-associated factors 1 and 2 in Hodgkin's disease.肿瘤坏死因子受体相关因子1和2在霍奇金病中的表达
J Pathol. 2001 Jun;194(2):158-64. doi: 10.1002/path.873.
5
Variation in the frequency of Epstein-Barr virus-associated Hodgkin's disease with age.
Leukemia. 2000 Apr;14(4):748-53. doi: 10.1038/sj.leu.2401724.
6
Hodgkin and reed-sternberg cells represent an expansion of a single clone originating from a germinal center B-cell with functional immunoglobulin gene rearrangements but defective immunoglobulin transcription.霍奇金和里德-斯腾伯格细胞代表了一个单一克隆的扩增，该克隆起源于具有功能性免疫球蛋白基因重排但免疫球蛋白转录缺陷的生发中心B细胞。
Blood. 2000 Feb 15;95(4):1443-50.
7
Quantitative immunohistochemical analysis of cytokine profiles in Epstein-Barr virus-positive and -negative cases of Hodgkin's disease.霍奇金淋巴瘤中爱泼斯坦-巴尔病毒阳性和阴性病例细胞因子谱的定量免疫组化分析
J Pathol. 2000 Feb;190(2):143-9. doi: 10.1002/(SICI)1096-9896(200002)190:2<143::AID-PATH519>3.0.CO;2-5.
8
Clonal deleterious mutations in the IkappaBalpha gene in the malignant cells in Hodgkin's lymphoma.霍奇金淋巴瘤恶性细胞中IκBα基因的克隆性有害突变。
J Exp Med. 2000 Jan 17;191(2):395-402. doi: 10.1084/jem.191.2.395.
9
Rare occurrence of classical Hodgkin's disease as a T cell lymphoma.经典型霍奇金淋巴瘤罕见地表现为T细胞淋巴瘤。
J Exp Med. 2000 Jan 17;191(2):387-94. doi: 10.1084/jem.191.2.387.
10
Detection of Epstein-Barr virus in Hodgkin-Reed-Sternberg cells : no evidence for the persistence of integrated viral fragments inLatent membrane protein-1 (LMP-1)-negative classical Hodgkin's disease.霍奇金-里德-斯腾伯格细胞中爱泼斯坦-巴尔病毒的检测：在潜伏膜蛋白-1（LMP-1）阴性的经典霍奇金淋巴瘤中不存在整合病毒片段持续存在的证据
Am J Pathol. 2000 Jan;156(1):209-16. doi: 10.1016/S0002-9440(10)64721-9.
Zotero 插件