Hayakawa T, Nagai Y, Taniguchi M, Yamashita H, Takamura T, Abe T, Nomura G, Kobayashi K
First Department of Internal Medicine, School of Medicine, Kanazawa University, Japan.
Metabolism. 2000 Nov;49(11):1506-9. doi: 10.1053/meta.2000.17710.
Given that the NcoI polymorphism of the tumor necrosis factor-beta (TNF-beta) gene has been shown to be associated with tumor necrosis factor-alpha (TNF-alpha) secretory capacity, we know that this TNF-beta gene polymorphism may influence insulin resistance. In Caucasians, 2 polymorphisms of the TNF-alpha promoter region (positions -308 and -238) have been reported to be associated with insulin resistance. Thus, we investigated how genetic variation in the TNF-beta and TNF-alpha genes was associated with insulin resistance in 211 Japanese men. The frequency of the TNF-beta gene polymorphism was 0.41, and insulin resistance, estimated by homeostasis model assessment (HOMA), was significantly lower in variant homozygotes versus wild-type allele. The frequencies of the -308 and -238 polymorphisms were 0.01 and 0.02, respectively, and these polymorphisms were not associated with insulin resistance. Our results suggest that the TNF-beta gene polymorphism decreases insulin resistance, and that the -308 and -238 polymorphisms of the TNF-alpha promoter region are not a major contributing factor to insulin resistance in Japanese men.
鉴于肿瘤坏死因子-β（TNF-β）基因的NcoI多态性已被证明与肿瘤坏死因子-α（TNF-α）的分泌能力相关，我们知道这种TNF-β基因多态性可能会影响胰岛素抵抗。在白种人中，据报道TNF-α启动子区域的两种多态性（-308和-238位点）与胰岛素抵抗有关。因此，我们研究了211名日本男性中TNF-β和TNF-α基因的遗传变异与胰岛素抵抗之间的关系。TNF-β基因多态性的频率为0.41，通过稳态模型评估（HOMA）估算的胰岛素抵抗在变异纯合子中显著低于野生型等位基因。-308和-238多态性的频率分别为0.01和0.02，且这些多态性与胰岛素抵抗无关。我们的结果表明，TNF-β基因多态性会降低胰岛素抵抗，并且TNF-α启动子区域的-308和-238多态性不是日本男性胰岛素抵抗的主要影响因素。
