Caterina J J, Shi J, Kozak C A, Engler J A, Birkedal-Hansen H
The National Institute of Dental and Craniofacial Research, Bethesda, MD, USA.
Mol Biol Rep. 2000 Jun;27(2):73-9. doi: 10.1023/a:1007196529604.
Using homology-based database screening, we have identified the mouse homologue for the recently described matrix metalloproteinase-19 (MMP-19). Sequencing of mouse MMP-19 resulted in a putative open reading frame (ORF) of 527 amino acids showing 84% identity to the human homologue. In mouse, MMP-19 appears to be most highly expressed in the liver; however, there is a detectable level of expression in all tissues analyzed. The major mouse MMP-19 transcript is almost twice as long as that of human. The COOH-terminal serine and threonine-rich domain is considerably longer in the mouse homologue. The mouse MMP-19 gene maps to very distal end of mouse chromosome 10.
