狭叶萝芙木对大鼠单胺氧化酶和胆碱酯酶活性及脑内生物胺水平的影响。

Effect of Rhazya stricta Decne on monoamine oxidase and cholinesterase activity and brain biogenic amine levels in rats.

作者信息

Ali B H, Tanira M O, Bashir A K, Al-Qarawi A A

机构信息

Department of Pharmacology, College of Medicine, Sultan Qaboos University, Sultanate of Oman, Saudi Arabia.

出版信息

J Pharm Pharmacol. 2000 Oct;52(10):1297-300. doi: 10.1211/0022357001777289.

DOI:10.1211/0022357001777289

PMID:11092575

Abstract

The effect of treatment with the medicinal plant Rhayva stricta Decne, on monoamine oxidase (MAO) and cholinesterase activity, and on the concentration of brain biogenic amines was studied in rats. R. stricta extract, at doses of 0.2 and 0.5 g kg(-1), significantly (P < 0.05-0.01) increased the hepatic and cerebral activity of MAO by 36-127%. The higher doses used (2.0 and 8.0 g kg(-1)) produced smaller (10-26%) and statistically insignificant increases in MAO activity in liver and brain. Cholinesterase activity in blood, liver and brain was not significantly influenced by treatment with R. stricta. The concentrations of the measured biogenic amines (noradrenaline, adrenaline, 5-hydroxytryptamine and dopamine) were significantly lowered in rats treated with R. stricta. The observed increase in MAO activity may be responsible for the lowered biogenic amines levels and may, in part, be responsible for the pharmacological effects of R. stricta extract in rats.

摘要

研究了药用植物刺山柑（Rhayva stricta Decne）对大鼠单胺氧化酶（MAO）和胆碱酯酶活性以及脑内生物胺浓度的影响。刺山柑提取物剂量为0.2和0.5 g·kg⁻¹时，显著（P<0.05 - 0.01）提高了肝脏和大脑中MAO的活性，增幅为36% - 127%。较高剂量（2.0和8.0 g·kg⁻¹）使肝脏和大脑中MAO活性的升高幅度较小（10% - 26%），且无统计学意义。刺山柑处理对血液、肝脏和大脑中的胆碱酯酶活性无显著影响。用刺山柑处理的大鼠中，所测生物胺（去甲肾上腺素、肾上腺素、5-羟色胺和多巴胺）的浓度显著降低。观察到的MAO活性增加可能是生物胺水平降低的原因，并且可能部分解释了刺山柑提取物对大鼠的药理作用。