Ali B H, Alqarawi A A, Bashir A K, Tanira M O
Department of Veterinary Medicine, College of Agriculture and Veterinary Medicine, King Saud University, P. O. Box 1482 Buryadah, Al-Gaseem, Saudi Arabia.
Phytother Res. 2000 Sep;14(6):469-71. doi: 10.1002/1099-1573(200009)14:6<469::aid-ptr612>3.0.co;2-w.
The effects of a leaf extract of the traditional medicinal plant Rhazya stricta (0.25, 1.0 and 4.0 g/kg/day for 3 days) on reduced glutathione (GSH), lipid peroxidation (LP) and ascorbic acid (AA) concentrations in the liver and kidneys were studied in rats 24 h after the last dose. The plant extract, at a dose of 0.25 g/kg, did not significantly affect the concentrations of GSH, LP or AA in the liver or kidneys. At a dose of 1.0 g/kg, the plant extract significantly increased the GSH concentration in the liver, but did not affect the GSH concentration in the kidneys, or LP or AA in the liver or kidneys. The plant extract (4.0 g/kg) significantly increased the GSH and decreased LP peroxidation, but did not affect the AA concentrations in the liver and kidneys. It may be concluded that the R. stricta extract, at some of the doses used, has antioxidant actions in the rat.
研究了传统药用植物刺山柑叶提取物（0.25、1.0和4.0克/千克/天，连续3天）对大鼠末次给药24小时后肝脏和肾脏中还原型谷胱甘肽（GSH）、脂质过氧化（LP）和抗坏血酸（AA）浓度的影响。剂量为0.25克/千克的植物提取物对肝脏或肾脏中GSH、LP或AA的浓度没有显著影响。剂量为1.0克/千克时，植物提取物显著提高了肝脏中GSH的浓度，但不影响肾脏中GSH的浓度，也不影响肝脏或肾脏中的LP或AA。植物提取物（4.0克/千克）显著提高了GSH并降低了LP过氧化，但不影响肝脏和肾脏中AA的浓度。可以得出结论，在所使用的某些剂量下，刺山柑提取物在大鼠体内具有抗氧化作用。
