Kurihara K, Shimizu S, Chong J, Hishima T, Funata N, Kashiwagi H, Nagai H, Miyaki M, Fukayama M
Department of Pathology, Jichi Medical School, Kawachi, Tochigi 329-0498, Japan.
Jpn J Cancer Res. 2000 Nov;91(11):1100-2. doi: 10.1111/j.1349-7006.2000.tb00891.x.
Thyroid carcinoma is the first symptom in some patients with familial adenomatous polyposis (FAP). We evaluated the cellular localization of beta-catenin in thyroid carcinomas associated (n = 4) or not associated (n = 173) with FAP, since loss of functional protein of the adenomatous polyposis coli (APC) gene leads to nuclear accumulation of beta-catenin in adenomas and carcinomas of the FAP colon. Immunoreactive beta-catenin was demonstrated at the cell membrane of glandular cells of the non-neoplastic thyroid and non-FAP carcinomas. On the other hand, cytoplasmic and nuclear accumulation of beta-catenin is specific to FAP-associated papillary carcinomas. The abnormality in the APC / beta-catenin pathway is thus also important in FAP-associated thyroid carcinoma, and beta-catenin immunohistochemistry is a feasible screening method to identify occult FAP in young patients with thyroid tumors.
甲状腺癌是一些家族性腺瘤性息肉病（FAP）患者的首发症状。我们评估了β-连环蛋白在与FAP相关（n = 4）或不相关（n = 173）的甲状腺癌中的细胞定位，因为腺瘤性息肉病 coli（APC）基因功能蛋白的缺失会导致FAP结肠腺瘤和癌中β-连环蛋白的核内积聚。在非肿瘤性甲状腺和非FAP癌的腺细胞细胞膜上可检测到免疫反应性β-连环蛋白。另一方面，β-连环蛋白的细胞质和核内积聚是FAP相关乳头状癌所特有的。因此，APC/β-连环蛋白通路的异常在FAP相关甲状腺癌中也很重要，β-连环蛋白免疫组化是一种可行的筛查方法，可用于识别年轻甲状腺肿瘤患者中的隐匿性FAP。
