Langosch J M, Zhou X Y, Grunze H, Walden J
Department of Psychiatry, University of Freiburg Medical School, Freiburg i.Br., Germany.
Neuropsychobiology. 2000;42 Suppl 1:26-7. doi: 10.1159/000054848.
This study was aimed at investigating the effects of lamotrigine (LTG) on electrically evoked field excitatory postsynaptic potentials (fEPSP) and population spikes in the CA1 hippocampal region of guinea pigs. The concentration response curves showed different actions of LTG on fEPSP and on population spikes. The data are in contrast to previous findings that suggest the drug acts primarily on presynaptic sites via a blockade of the release of excitatory amino acids. In the range of therapeutic plasma levels, synaptic transmission was not affected.
本研究旨在探讨拉莫三嗪（LTG）对豚鼠海马CA1区电诱发的场兴奋性突触后电位（fEPSP）和群体峰电位的影响。浓度-反应曲线显示，LTG对fEPSP和群体峰电位具有不同的作用。这些数据与之前的研究结果相反，之前的研究表明该药物主要通过阻断兴奋性氨基酸的释放作用于突触前位点。在治疗性血浆浓度范围内，突触传递未受影响。
