Dong P, Guan Y, Yang J, He M, Wan C
Beijing Anzhen Hospital, Beijing Capital Medical University, Beijing Heart, Lung and Blood Vessel Medical Institute, People's Republic of China.
Ann Thorac Surg. 2000 Nov;70(5):1478-82. doi: 10.1016/s0003-4975(00)01836-1.
Retrograde cerebral perfusion (RCP) through the superior vena cava was clinically introduced as a supportive technique to protect the brain during deep hypothermic circulatory arrest. This study searched for a direct monitor of cerebral blood flow to evaluate the effect of cerebral perfusion.
Retinal microvascular perfusions were studied in six piglets using fundus fluorescein angiography (FFA) and color Doppler sonography before cardiopulmonary bypass and retrograde cerebral perfusion during deep hypothermic circulatory arrest.
FFA showed initial filling of the fundus venae in 2.5 minutes, and complete filling in 4.5 minutes with partial filling of the arteriae. Arteriae completely filled in 8 minutes, and all of the arteriae and venae filled from 15 to 17 minutes. Color Doppler sonography showed that flow signals were detected in all of the fundus vessels during RCP.
FFA and color Doppler sonography are direct and sensitive methods for observing cerebral blood flow and assessing the effect of cerebral perfusion.
经上腔静脉逆行脑灌注（RCP）作为一种支持技术在临床上被引入，用于在深度低温循环停搏期间保护大脑。本研究寻找一种脑血流的直接监测方法以评估脑灌注效果。
在6只仔猪中，于体外循环及深度低温循环停搏期间逆行脑灌注前，使用眼底荧光血管造影（FFA）和彩色多普勒超声研究视网膜微血管灌注情况。
FFA显示眼底静脉在2.5分钟开始充盈，4.5分钟完全充盈，动脉部分充盈。动脉在8分钟完全充盈，所有动静脉在15至17分钟充盈。彩色多普勒超声显示在RCP期间所有眼底血管均检测到血流信号。
FFA和彩色多普勒超声是观察脑血流及评估脑灌注效果的直接且敏感的方法。
