有机溶剂与结缔组织病的流行病学
Epidemiology of organic solvents and connective tissue disease.
作者信息
Garabrant D H, Dumas C
机构信息
Department of Environmental Health Sciences, University of Michigan, School of Public Health, Ann Arbor, Michigan 48109-2029, USA.
出版信息
Arthritis Res. 2000;2(1):5-15. doi: 10.1186/ar65. Epub 1999 Dec 1.
Case reports suggest that solvents are associated with various connective tissue diseases (systemic sclerosis, scleroderma, undifferentiated connective tissue disease, systemic lupus erythematosis, and rheumatoid arthritis), particularly systemic sclerosis. A small number of epidemiological studies have shown statistically significant but weak associations between solvent exposure, systemic sclerosis, and undifferentiated connective tissue disease. However, the interpretation of these positive findings is tempered by a lack of replication, an inability to specify which solvents convey risk, and an absence of increasing risk with increasing exposure. Existing studies, on aggregate, do not show conclusively that solvents (either as a group of chemicals or individual chemicals) are causally associated with any connective tissue disease. Further investigations should be carried out to replicate the positive existing findings and to specify the solvents and circumstances of exposure that carry risk.
病例报告表明，溶剂与各种结缔组织疾病（系统性硬化症、硬皮病、未分化结缔组织病、系统性红斑狼疮和类风湿性关节炎）有关，尤其是系统性硬化症。少数流行病学研究表明，溶剂暴露、系统性硬化症和未分化结缔组织病之间存在统计学上显著但较弱的关联。然而，由于缺乏重复性、无法确定哪些溶剂会带来风险以及不存在暴露增加风险也增加的情况，这些阳性结果的解释受到了影响。总体而言，现有研究并未确凿表明溶剂（作为一组化学品或个别化学品）与任何结缔组织疾病存在因果关联。应进一步开展调查，以重复现有的阳性结果，并确定存在风险的溶剂和暴露情况。
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