死亡、自身抗原修饰与耐受性。
Death, autoantigen modifications, and tolerance.
作者信息
Utz P J, Gensler T J, Anderson P
机构信息
Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA.
出版信息
Arthritis Res. 2000;2(2):101-14. doi: 10.1186/ar75. Epub 2000 Feb 9.
Abstract
Autoantibodies present in the serum of patients with a variety of inflammatory diseases have proven useful as diagnostic markers and as probes with which to elucidate biochemical and signaling pathways. The mechanisms governing the generation of autoantibodies remain elusive, constituting a critical missing link in our understanding of rheumatologic illnesses. Several lines of experimentation in recent years have strongly implicated events surrounding cell death in this process. This review will address the potential role played by death-specific modifications of autoantigens in bypassing tolerance to highly conserved autoantigens, including nucleic acids, lipids, and proteins.
摘要
存在于多种炎症性疾病患者血清中的自身抗体已被证明可作为诊断标志物以及用于阐明生化和信号通路的探针。自身抗体产生的机制仍然难以捉摸，这是我们理解风湿性疾病过程中关键的缺失环节。近年来的多项实验有力地表明细胞死亡相关事件在此过程中发挥了作用。本综述将探讨自身抗原的死亡特异性修饰在绕过对高度保守自身抗原（包括核酸、脂质和蛋白质）的耐受性方面所起的潜在作用。
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