主要组织相容性复合体（MHC）与类风湿性关节炎的关联。类风湿性关节炎动物模型中HLA II类分子的调节作用：对转基因/基因敲除小鼠的研究。
Association of MHC and rheumatoid arthritis. Regulatory role of HLA class II molecules in animal models of RA: studies on transgenic/knockout mice.
作者信息
Taneja V, David C S
机构信息
Department of Immunology, Mayo Clinic, Rochester, Minnesota 55905, USA.
出版信息
Arthritis Res. 2000;2(3):205-7. doi: 10.1186/ar88. Epub 2000 Apr 12.
Abstract
Human leucocyte antigen (HLA) class II molecules have been shown to be associated with predisposition to rheumatoid arthritis (RA). We generated HLA-DR and DQ transgenic mice that lacked endogenous class II molecules to study the interaction between the DR and DQ molecules and define the immunologic mechanisms in rheumatoid arthritis. Using collagen-induced arthritis (CIA) as an experimental model for inflammatory polyarthritis, we show that both DQ and DR are involved in predisposition or resistance to arthritis. Our studies suggest that polymorphism in DQB1 genes may determine predisposition to RA while the DRB1 polymorphism may dictate severity/protection of the disease. These mice provide powerful tools to develop immunotherapeutic protocols.
摘要
人类白细胞抗原（HLA）II类分子已被证明与类风湿关节炎（RA）的易感性相关。我们培育了缺乏内源性II类分子的HLA-DR和DQ转基因小鼠，以研究DR和DQ分子之间的相互作用，并确定类风湿关节炎的免疫机制。使用胶原诱导的关节炎（CIA）作为炎症性多关节炎的实验模型，我们发现DQ和DR都与关节炎的易感性或抵抗力有关。我们的研究表明，DQB1基因的多态性可能决定RA的易感性，而DRB1多态性可能决定疾病的严重程度/保护性。这些小鼠为开发免疫治疗方案提供了强大的工具。
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