Zanelli E, Gonzalez-Gay M A, David C S
Dept of Immunology, Mayo Clinic, Rochester, MN 55905, USA.
Immunol Today. 1995 Jun;16(6):274-8. doi: 10.1016/0167-5699(95)80181-2.
Extensive studies in different ethnic groups have associated the susceptibility to development of rheumatoid arthritis (RA) with the third hypervariable region of the major histocompatibility complex (MHC) HLA-DR beta 1 molecule. On the basis of recent findings in the experimental mouse model of collagen-induced arthritis, Eric Zanelli, Miguel Gonzalez-Gay and Chella David propose that the HLA-DRB1 locus is associated with protection to RA and that the actual arthritogenic peptide-presenting molecule is HLA-DQ. Thus, the development of RA would depend upon the expression of the susceptible DQ allele and the nonprotective DRB1 alleles, along with environmental factors that trigger the autoimmune process.
在不同种族群体中进行的广泛研究已将类风湿性关节炎（RA）的易感性与主要组织相容性复合体（MHC）HLA - DRβ1分子的第三个高变区联系起来。基于胶原诱导性关节炎实验小鼠模型的最新发现，埃里克·扎内利、米格尔·冈萨雷斯 - 盖伊和切拉·大卫提出，HLA - DRB1基因座与对RA的保护相关，而实际引发关节炎的肽呈递分子是HLA - DQ。因此，RA的发展将取决于易感DQ等位基因和无保护作用的DRB1等位基因的表达，以及触发自身免疫过程的环境因素。
