人类白细胞抗原II类分子与类风湿关节炎的关联：事实与解读。

HLA class II association with rheumatoid arthritis: facts and interpretations.

作者信息

Zanelli E, Breedveld F C, de Vries R R

机构信息

Department of Immunohematology and Blood Transfusion, University Medical Center, Leiden, The Netherlands.

出版信息

Hum Immunol. 2000 Dec;61(12):1254-61. doi: 10.1016/s0198-8859(00)00185-3.

DOI:10.1016/s0198-8859(00)00185-3

PMID:11163080

Abstract

We have reviewed the literature on the association of HLA class II with rheumatoid arthritis (RA). Strong linkage disequilibrium among DQB1, DQA1 and DRB1 alleles makes it difficult to evaluate the individual contribution of each locus. Nonetheless, there is a strong case for the role of DQB103 and 04 combined with DQA103 in susceptibility to severe RA while DQB10501 combined with DQA1*0101 and 0104 weakly predisposes to a mild form of RA. However, it is also clear that DRB10401 has a particular role in predisposition to the most severe form of the disease while other DRB1 alleles might provide protection. We would like to propose that in RA, as in type I diabetes, both DQ and DR loci contribute to predisposition to the disease.

摘要

我们回顾了关于人类白细胞抗原（HLA）II类分子与类风湿关节炎（RA）关联的文献。DQB1、DQA1和DRB1等位基因之间存在强烈的连锁不平衡，这使得评估每个基因座的个体贡献变得困难。尽管如此，有充分的证据表明，DQB103和04与DQA103组合在严重RA易感性中起作用，而DQB10501与DQA10101和0104组合则弱倾向于轻度RA形式。然而，同样清楚的是，DRB1*0401在该疾病最严重形式的易感性中具有特殊作用，而其他DRB1等位基因可能提供保护。我们建议，在RA中，如同在I型糖尿病中一样，DQ和DR基因座都对疾病易感性有影响。