成纤维细胞生物学。关节炎中滑膜成纤维细胞的发育与分化。
Fibroblast biology. Development and differentiation of synovial fibroblasts in arthritis.
作者信息
Edwards J C
机构信息
UCL Centre for Rheumatology, London, UK.
出版信息
Arthritis Res. 2000;2(5):344-7. doi: 10.1186/ar110. Epub 2000 Jun 8.
Abstract
Synovial fibroblasts occur as two phenotypes--intimal and subintimal. The specialised intimal phenotype includes expression of uridine diphosphoglucose dehydrogenase (UDPGD), vascular cell adhesion molecule-1 (VCAM-1) and complement decay-accelerating factor (DAF). These gene products contribute to specialised functions relating to tissue movement and leucocyte traffic.
摘要
滑膜成纤维细胞有两种表型——内膜型和内膜下型。特殊的内膜型表型包括尿苷二磷酸葡萄糖脱氢酶（UDPGD）、血管细胞黏附分子-1（VCAM-1）和补体衰变加速因子（DAF）的表达。这些基因产物有助于与组织运动和白细胞运输相关的特殊功能。
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