败血症和脓毒性休克的重大进展。
Critical advances in septicemia and septic shock.
作者信息
Das U N
机构信息
EFA Sciences LLC, Norwood, Massachusetts 02062, USA.
出版信息
Crit Care. 2000;4(5):290-6. doi: 10.1186/cc711. Epub 2000 Sep 7.
Abstract
Recent advances suggest that toll-like receptors, various cytokines, cicosanoids, free radicals and macrophage migration inhibitory factor (MIF) play an important role in the pathobiology of septicemia and septic shock. Anti-MIF antibodies can decrease the plasma concentrations of tumor necrosis factor (TNF), lower bacterial circulating counts and enhance survival of animals with septicemia and septic shock. Monocyte expression of MHC-class II antigens, neutrophil expression of the integrin CD11b/CD18 and neutrophil activation can be related to the development of, and/or recovery from, post-operative sepsis. Thus, biological variations in the response of an individual to a given stimulus, appears to determine his/her ability or inability to develop and also recover from sepsis and septic shock. This suggests that it may be possible to predict the development of septicemia and septic shock in a given individual and take appropriate action both to prevent and treat them adequately.
摘要
近期的研究进展表明， Toll样受体、多种细胞因子、类二十烷酸、自由基和巨噬细胞移动抑制因子（MIF）在败血症和脓毒性休克的病理生物学过程中发挥着重要作用。抗MIF抗体可降低肿瘤坏死因子（TNF）的血浆浓度，减少细菌循环数量，并提高败血症和脓毒性休克动物的存活率。单核细胞MHC-II类抗原的表达、中性粒细胞整合素CD11b/CD18的表达以及中性粒细胞的激活可能与术后败血症的发生和/或恢复有关。因此，个体对给定刺激的反应中的生物学差异似乎决定了其发生败血症和脓毒性休克以及从中恢复的能力。这表明，有可能预测特定个体发生败血症和脓毒性休克的情况，并采取适当措施进行预防和充分治疗。
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