Vuadens P
Clinique romande de réadaptation, Sion.
Rev Med Suisse Romande. 2000 Sep;120(9):717-24.
The mechanisms that enhance recovery from brain lesion are more and more precise. The role of neurotransmitters and post-synaptic receptors are essential. Different drugs acting at the level of synapses are potentially useful but still few used in neurorehabilitation. The aim of this article is to review the drugs that can be prescribed in selected situation. In spite of encouraging results of numerous studies, a lot of questions remain and prove the need of large randomised studies to determine the real benefit of drugs in rehabilitation. Moreover, if the activation of neurotransmitters can improve recovery, all their antagonists will produce the inverse effect. Therefore, the choice of drugs in neurorehabilitation is essential.
促进脑损伤恢复的机制越来越精确。神经递质和突触后受体的作用至关重要。作用于突触水平的不同药物可能有用，但在神经康复中仍很少使用。本文的目的是综述在特定情况下可开具处方的药物。尽管众多研究取得了令人鼓舞的结果，但仍有许多问题存在，这证明需要进行大量随机研究来确定药物在康复中的实际益处。此外，如果神经递质的激活能改善恢复，那么它们所有的拮抗剂都会产生相反的效果。因此，神经康复中药物的选择至关重要。
