Rösser Nina, Flöel Agnes
Department of Neurology and IZKF Münster, University of Münster, Münster, Germany.
NeuroRehabilitation. 2008;23(1):95-103.
Pharmacological agents, known to modulate practice-dependent plasticity in animal models of brain damage, have recently received increased interest for treatment of motor recovery after stroke. The present paper gives an overview of agents that are currently available. Amphetamines have been repeatedly shown to promote recovery of function in animals, but clinical data remain inconclusive. Other pharmacological agents evaluated for motor recovery include selective norepinephrine re-uptake inhibitors, dopamine, dopamine agonists, cholinergic substances, serotonin re-uptake inhibitors, and granulocyte-colony stimulating factor. Although preliminary data from animal and human experimental studies on these agents are promising, larger clinical trials are needed before any of the available agents may be recommended for routine use.
已知在脑损伤动物模型中可调节依赖练习的可塑性的药物制剂，最近在中风后运动恢复治疗方面受到了越来越多的关注。本文概述了目前可用的制剂。苯丙胺已被反复证明可促进动物的功能恢复，但临床数据仍无定论。评估用于运动恢复的其他药物制剂包括选择性去甲肾上腺素再摄取抑制剂、多巴胺、多巴胺激动剂、胆碱能物质、5-羟色胺再摄取抑制剂和粒细胞集落刺激因子。尽管来自动物和人体实验研究的关于这些制剂的初步数据很有前景，但在推荐任何一种可用制剂用于常规使用之前，还需要进行更大规模的临床试验。
