Grimes J B, Abel R M
JPEN J Parenter Enteral Nutr. 1979 Mar-Apr;3(2):40-4. doi: 10.1177/014860717900300201.
An intravenous infusion of Intralipid-10% was observed to exert a negative inotropic effect on left ventricular performance in a canine isovolumetric left heart preparation. There was no effect on diastolic compliance, however. Intravenous fat emulsion also produced significant decreases in systemic vascular resistance. The mechanism of these actions has not been elucidated, but it is postulated that free fatty acid (FFA) components or their metabolites directly affect the contractile properties of both myocardium and smooth muscle. These results suggest that until suitable clinical studies can be obtained, caution should be exercised in administering intravenous fat emulsions, particularly at maximum rates of infusion or in conjunction with sodium heparin in patients with known cardiac dysfunction.
在犬左心等容性制备模型中，观察到静脉输注10%的英脱利匹特（Intralipid）对左心室功能产生负性肌力作用。然而，对舒张顺应性没有影响。静脉脂肪乳剂还可使体循环血管阻力显著降低。这些作用的机制尚未阐明，但据推测，游离脂肪酸（FFA）成分或其代谢产物直接影响心肌和平滑肌的收缩特性。这些结果表明，在获得适当的临床研究之前，在给予静脉脂肪乳剂时应谨慎，特别是在最大输注速率下或与已知有心脏功能障碍的患者联合使用肝素钠时。
