Fisch D, Abel R M
JPEN J Parenter Enteral Nutr. 1981 Sep-Oct;5(5):402-5. doi: 10.1177/0148607181005005402.
Two intravenous fat emulsions (Liposyn 10%, Abbott Laboratories, North Chicago, IL, and Intralipid 10%, Cutter Laboratories, Berkeley, CA) were evaluated in 13 adult patients following cardiopulmonary bypass procedures in a randomized, prospective, double-blind study to determine their overall hemodynamic effects. The fat emulsions were administered for 30 minutes, and each patient was his own control. Neither intravenous fat emulsion was observed to exert significant changes in left ventricular stroke work, left ventricular filling pressure, cardiac output, systemic vascular resistance, mean systemic arterial blood pressure, central venous pressure, or mean pulmonary artery pressure. This study confirmed that the administration of 10% fat emulsions available in the United States does not exert significant untoward hemodynamic changes, even in patients with severe cardiac impairment recovering from recent open heart surgery.
在一项随机、前瞻性、双盲研究中，对13例接受体外循环手术的成年患者评估了两种静脉脂肪乳剂（10% Liposyn，雅培实验室，伊利诺伊州北芝加哥；10% Intralipid，卡特实验室，加利福尼亚州伯克利），以确定它们的总体血流动力学效应。脂肪乳剂输注30分钟，每位患者以自身作为对照。未观察到两种静脉脂肪乳剂使左心室搏功、左心室充盈压、心输出量、全身血管阻力、平均体动脉血压、中心静脉压或平均肺动脉压发生显著变化。该研究证实，即使是近期接受心脏直视手术且有严重心脏功能损害的患者，使用美国现有的10%脂肪乳剂也不会产生显著的不良血流动力学变化。
