Kivilcim M, Peyman G A, El-Dessouky E S, Kazi A A, Cheema R, Hegazy H
LSU Eye Center, Louisiana State University Medical Center School of Medicine, New Orleans, USA.
Ophthalmic Surg Lasers. 2000 Nov-Dec;31(6):474-8.
To determine the retinal toxicity of triamcinolone acetonide at different doses in vitrectomized, silicone-filled rabbit eyes.
Vitrectomy with silicone oil placement was performed in 32 rabbit eyes. A dosage of 1 mg/0.025 mL, 2 mg/0.05 mL, or 4 mg/0.1 mL of triamcinolone acetonide was injected intravitreally in the study group eyes; the control group received 0.1 mL of sterile saline. Electroretinography and retinal histology were performed to evaluate toxicity.
No retinal toxicity was seen in the groups given 1, 2, and 4 mg of triamcinolone acetonide or in the control group. ERG and histologic sections in all groups were normal. No drug was visible in the vitreous cavity at the end of the 140-day period (average) in eyes injected with 4 mg of triamcinolone acetonide.
Up to 4 mg of triamcinolone acetonide can be safely injected in silicone-filled, vitrectomized eyes without any significant retinal toxicity.
确定不同剂量曲安奈德对玻璃体切除联合硅油填充兔眼的视网膜毒性。
对32只兔眼进行玻璃体切除并注入硅油。研究组眼内注射剂量为1mg/0.025mL、2mg/0.05mL或4mg/0.1mL的曲安奈德；对照组接受0.1mL无菌生理盐水。通过视网膜电图和视网膜组织学检查评估毒性。
给予1mg、2mg和4mg曲安奈德的组以及对照组均未观察到视网膜毒性。所有组的视网膜电图和组织学切片均正常。在注射4mg曲安奈德的眼中，140天（平均）结束时玻璃体腔内未见药物。
在玻璃体切除联合硅油填充的眼中，安全注射高达4mg曲安奈德不会产生任何明显的视网膜毒性。
