Clagett G P, Schneider P, Rosoff C B, Salzman E W
Surgery. 1975 Jan;77(1):61-74.
Several parameters of platelet kinetics were followed in 105 middle-aged and elderly postoperative patients, half of whom were randomly allocated to receive aspirin. A significantly lower incidence of venous thrombosis, as detected by 125I-fibrinogen scanning, was found among patients receiving aspirin when compared with the control group. Platelet survival was shortened in the postoperative state, an effect that was inhibited by aspirin. The development of deep vein thrombosis did not shorten platelet survival, nor did fibrinogen survival discriminate patients with venous thrombosis. Treatment with aspirin reduced urinary excretion of 5-hydroxy indole acetic acid--presumably by inhibiting in vivo platelet release of serotonin, reduced postoperative consumption of platelets, and reduced the mean corpuscular volume of the platelet population. These studies suggest that platelet function is important in the pathogenesis of postoperative venous thrombosis.
对105例中老年术后患者的血小板动力学的几个参数进行了跟踪研究，其中一半患者被随机分配接受阿司匹林治疗。与对照组相比，通过125I-纤维蛋白原扫描检测发现，接受阿司匹林治疗的患者静脉血栓形成的发生率显著降低。术后血小板生存期缩短，而阿司匹林可抑制这一效应。深静脉血栓形成的发展并未缩短血小板生存期，纤维蛋白原生存期也不能区分静脉血栓形成患者。阿司匹林治疗可减少5-羟吲哚乙酸的尿排泄——可能是通过抑制体内血小板释放5-羟色胺，减少术后血小板消耗，并降低血小板群体的平均细胞体积。这些研究表明，血小板功能在术后静脉血栓形成的发病机制中很重要。
