Mosso J A, Rand R W
West J Med. 1975 Jan;122(1):1-6.
An increasing number of parkinsonian patients in whom levodopa fails to relieve tremor are being referred for thalamotomy. The literature suggests that in as many as 50 percent of patients treated with levodopa, there is no relief of tremor because of refractoriness to the medication or intractable side effects which limit dosage. Thalamotomy abolishes contralateral tremor in 90 percent of patients, with an associated mortality rate of 1 to 2 percent and morbidity of 6 percent. The relative merits and complications of levodopa and thalamotomy were reviewed and a therapeutic regimen designed in which the two approaches to treatment are combined to most effectively deal with all the symptoms of parkinsonism.
越来越多左旋多巴无法缓解震颤的帕金森病患者被转诊接受丘脑切开术。文献表明，在接受左旋多巴治疗的患者中，多达50%的患者因对药物难治或存在限制剂量的顽固性副作用而无法缓解震颤。丘脑切开术可消除90%患者的对侧震颤，相关死亡率为1%至2%，发病率为6%。对左旋多巴和丘脑切开术的相对优缺点及并发症进行了综述，并设计了一种治疗方案，将这两种治疗方法结合起来，以最有效地应对帕金森病的所有症状。
