RAND R W, MARKHAM C H
Calif Med. 1964 Oct;101(4):248-52.
In a review of 61 patients with Parkinson's disease who were treated by cryothalamectomy, the technique of freezing a surgical target as compared with destroying it by alcohol or thermal heat was found effective and to a degree safer than other techniques. One patient died of unexpected cerebral hemorrhage. Of patients considered excellent candidates for the operation, 80 per cent had excellent and good results, while those considered good candidates showed 85 per cent excellent and good results. The results are more dependent on the selection of the patient as a candidate and the diffuseness of the pathophysiological circuits involved than on the technical factors of the cryogenic procedure.
在一项对61例接受丘脑冷冻切除术治疗的帕金森病患者的回顾中，与用酒精或热破坏手术靶点相比，冷冻手术靶点的技术被发现是有效的，并且在一定程度上比其他技术更安全。1例患者死于意外脑出血。在被认为是该手术极佳候选者的患者中，80%取得了极佳和良好的效果，而被认为是良好候选者的患者中，这一比例为85%。结果更多地取决于患者作为候选者的选择以及所涉及病理生理回路的弥散程度，而非低温手术的技术因素。
