Rols M P, Bachaud J M, Giraud P, Chevreau C, Roché H, Teissié J
Institut de Pharmacologie et de Biologie Structurale du CNRS (UPR 9062), Toulouse, France.
Melanoma Res. 2000 Oct;10(5):468-74. doi: 10.1097/00008390-200010000-00009.
Electrochemotherapy is a new anticancer therapy in which transient permeabilization of cells by an electric field induces a significant increase in the bleomycin concentration and toxicity in tumour cells. We report a clinical study of electrochemotherapy in malignant melanoma. The main issues addressed were the effect of the size of the nodules, the optimization of the electrical parameters, and posttreatment clinical observations. Four patients were enrolled in the study. They received a 10 mg/m2 dose of bleomycin administered intravenously, followed by short, intense electric pulses applied directly to the skin at the tumour sites. Antitumour effects were obtained, especially in the smallest nodules. Objective responses were obtained in more than 90% of the 55 nodules treated, with a complete response rate of 9%. All patients tolerated the treatment well. No residual effects from the electric pulses were observed, even when a high number of pulses were required or when two consecutive treatments were applied. These results are encouraging and the study should be continued.
电化学疗法是一种新型抗癌疗法，电场使细胞产生瞬时通透性增加，从而导致肿瘤细胞中博来霉素浓度和毒性显著升高。我们报告了一项关于恶性黑色素电化学疗法的临床研究。主要探讨的问题包括结节大小的影响、电参数的优化以及治疗后的临床观察。该研究招募了4名患者。他们静脉注射10mg/m²剂量的博来霉素，随后将短而强的电脉冲直接施加于肿瘤部位的皮肤。取得了抗肿瘤效果，尤其是在最小的结节中。在接受治疗的55个结节中，超过90%获得了客观缓解，完全缓解率为9%。所有患者对治疗耐受性良好。即使需要大量脉冲或进行连续两次治疗，也未观察到电脉冲的残留影响。这些结果令人鼓舞，该研究应继续进行。
