关岛查莫罗人脊髓神经原纤维病变中的tau表位

Tau epitopes in spinal cord neurofibrillary lesions in Chamorros of Guam.

作者信息

Schmidt M L, Garruto R, Chen J, Lee V M, Trojanowski J Q

机构信息

Center for Neurodegenerative Disease, Research, Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania Medical School, Philadelphia 19104-4283, USA.

出版信息

Neuroreport. 2000 Nov 9;11(16):3427-30. doi: 10.1097/00001756-200011090-00005.

DOI:10.1097/00001756-200011090-00005

PMID:11095492

Abstract

We examined spinal cord sections from Guamanian Chamorros with or without amyotrophic lateral sclerosis or parkinsonism-dementia complex using immunohistochemistry and antibodies to epitopes that span the length of tau to characterize the tau epitope profile of neurofibrillary tangles in these spinal cords. Most (16/20) spinal cords, including some from Chamorros without documented clinical disease, contained tangles with a tau epitope profile similar to the tangles found in the forebrain and brain stem of these patients.

摘要

我们使用免疫组织化学方法，并针对跨越tau蛋白全长的表位的抗体，检查了患有或未患有肌萎缩侧索硬化症或帕金森病痴呆综合征的关岛查莫罗人的脊髓切片，以表征这些脊髓中神经原纤维缠结的tau表位谱。大多数（16/20）脊髓，包括一些没有记录在案的临床疾病的查莫罗人的脊髓，都含有tau表位谱与这些患者前脑和脑干中发现的缠结相似的缠结。