Matsumoto S, Hirano A, Goto S
Department of Pathology, Montefiore Medical Center, Bronx, NY 10467.
Neurology. 1990 Jun;40(6):975-9. doi: 10.1212/wnl.40.6.975.
We studied the topographic distribution and immunohistochemical characteristics of spinal cord neurofibrillary tangles (NFTs) in 6 patients with Guamanian amyotrophic lateral sclerosis (ALS) and 6 patients with parkinsonismdementia complex (PD) on Guam, using antibodies to tau protein and ubiquitin. The NFTs were immunoreactive with both antibodies, but staining for tau was more pronounced. As identified by this reactivity, all the Guamanian ALS and PD cases examined showed spinal cord NFTs. The posterior horn had the most and the anterior horn the least. In the posterior horn the NFTs were located mainly in the marginal areas. Large anterior horn cells showed few, if any, NFTs. In addition to perikaryal NFTs, we observed tau-reactive neurites. Our results provide evidence that spinal cord NFTs are not uncommon in Guamanian ALS and PD on Guam and that they are more numerous than previously found with conventional methods.
我们使用针对tau蛋白和泛素的抗体,研究了关岛6例关岛型肌萎缩侧索硬化症(ALS)患者和6例帕金森病痴呆综合征(PD)患者脊髓神经原纤维缠结(NFTs)的地形分布和免疫组化特征。NFTs与两种抗体均呈免疫反应,但tau染色更明显。通过这种反应性鉴定,所有检测的关岛型ALS和PD病例均显示脊髓NFTs。后角最多,前角最少。在后角,NFTs主要位于边缘区域。大型前角细胞即使有也很少有NFTs。除了核周NFTs,我们还观察到tau反应性神经突。我们的结果提供了证据,表明脊髓NFTs在关岛的关岛型ALS和PD中并不罕见,并且它们比以前用传统方法发现的数量更多。