Holmström B, Grimsley E W
Department of Internal Medicine Education, Memorial Health University Medical Center, Savannah, GA 31404, USA.
South Med J. 2000 Nov;93(11):1096-8.
A recent increase in reports of necrotizing fasciitis resulting from group B streptococcus has alerted physicians to a possible concomitant increase of toxic shock-like syndrome. We report the second case of group B streptococcus causing necrotizing fasciitis and toxic shock-like syndrome. A black woman, aged 52 years, with newly diagnosed diabetes mellitus had necrotizing fasciitis type II of the left groin. Hypotension, elevated bilirubin and liver enzymes, and adult respiratory distress syndrome rapidly developed. Because group B streptococcus was isolated from a normally sterile site, the patient's condition met the criteria for toxic shock-like syndrome. Extensive surgical debridement, hyperbaric oxygen therapy, and intravenous antibiotic therapy (including clindamycin) were required for complete recovery. The antitoxin effects of hyperbaric oxygen therapy and clindamycin should be further investigated for the treatment of such patients.
近期,B族链球菌所致坏死性筋膜炎的报告增多,这提醒医生注意中毒性休克样综合征可能也会随之增加。我们报告第二例由B族链球菌引起坏死性筋膜炎和中毒性休克样综合征的病例。一名52岁的黑人女性,新诊断为糖尿病,发生了左腹股沟II型坏死性筋膜炎。低血压、胆红素和肝酶升高以及成人呼吸窘迫综合征迅速出现。由于从通常无菌的部位分离出了B族链球菌,该患者的病情符合中毒性休克样综合征的标准。为实现完全康复,需要进行广泛的手术清创、高压氧治疗和静脉抗生素治疗(包括克林霉素)。对于此类患者的治疗,应进一步研究高压氧治疗和克林霉素的抗毒素作用。