McConnell S A, Penzak S R, Warmack T S, Anaissie E J, Gubbins P O
College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR 72205-7199, USA.
Clin Infect Dis. 2000 Dec;31(6):1512-4. doi: 10.1086/317507.
The purpose of this retrospective study was to assess cross-hypersensitivity between imipenem/cilastatin and penicillin in patients with reported penicillin allergies. Medical records of febrile neutropenic, penicillin-allergic bone marrow transplant recipients who received imipenem/cilastatin treatment were retrospectively reviewed. The findings of this study indicate the incidence of cross-reactivity between imipenem/cilastatin and penicillin among patients with a history of penicillin allergy may be lower than previously reported.
这项回顾性研究的目的是评估有青霉素过敏报告的患者中，亚胺培南/西司他丁与青霉素之间的交叉过敏反应。对接受亚胺培南/西司他丁治疗的发热性中性粒细胞减少且对青霉素过敏的骨髓移植受者的病历进行了回顾性分析。本研究结果表明，有青霉素过敏史的患者中，亚胺培南/西司他丁与青霉素之间交叉反应的发生率可能低于先前报道。
