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猪和狗失血性休克后肺水的早期变化

Early changes in lung water after haemorrhagic shock in pigs and dogs.

作者信息

Noble W H

出版信息

Can Anaesth Soc J. 1975 Jan;22(1):39-49. doi: 10.1007/BF03004817.

Abstract

This study has demonstrated a 34 per cent rise in lung water after shock and retransfusion of blood. This extra lung water was associated with increased pulmonary artery pressure, increased plumonary vascular resistance and reduced myocardial performance. These findings occurred despite the failure of arterial pressure to return to normal after retransfusion blood. Although this increased lung water is less than anything which can be detected clinically it may represent the beginnings of the shock lung syndrome as oedema progresses over period of weeks. A reasonable approach to the problem should include attempts to reduce the elevated plumonary vascular resistance. NaHCO3 should be infused before or during administration of the first bottle of blood in an attempt to improve myocardial function and reduce pulmonary vascular resistance. Fluids should not be infused simply to return arterial pressures in the pulmonary vascular bed. Pulmonary artery and wedge pressure monitoring with Swan Ganz catheters may improve the management of shock patients.

摘要

本研究表明,休克及输血后肺水量增加了34%。这些额外的肺水与肺动脉压升高、肺血管阻力增加及心肌功能降低有关。尽管输血后动脉压未能恢复正常,但仍出现了这些 findings。虽然这种增加的肺水量小于临床可检测到的任何量,但随着水肿在数周内进展,它可能代表着休克肺综合征的开端。解决该问题的合理方法应包括尝试降低升高的肺血管阻力。应在输注第一瓶血液之前或期间输注碳酸氢钠,以试图改善心肌功能并降低肺血管阻力。不应仅仅为了恢复肺血管床的动脉压而输注液体。使用 Swan Ganz 导管监测肺动脉和楔压可能会改善对休克患者的管理。

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