Famewo C E, Noble W H, Garvey M B
Can Anaesth Soc J. 1975 Jan;22(1):50-60. doi: 10.1007/BF03004818.
Haemorrhagic shock was induced in two similar groups of dogs for two hours. One group received aspirin before shock and the other group served as a control. When blood was retransfused the PVR which was markedly elevated during shock returned to pre-shock value in the aspirin group but was elevated 100 per cent in the control group, despite correction of a cidosis. Aspirin reduces collagen-induced platelet aggregation and thereby inhibits the formation of platelet micro-emboli without affecting the coagulationfactors. This effect of aspirin is thought to be responsible for the lowering of the elevated PVR to pre-shock values in the aspirin group following retransfusion. Because of the metabolic acidosis associated with the shock state, concurrent administration of sodium bicarbonate is recommended when transfusing shocked patients with blood. A clinical trial of aspirin in early treatment of shocked patients as well as for prophylaxis in high risk situations is justified.
在两组相似的犬中诱导出血性休克两小时。一组在休克前给予阿司匹林，另一组作为对照。当输血时，休克期间显著升高的肺血管阻力（PVR）在阿司匹林组恢复到休克前值，但在对照组中尽管纠正了酸中毒仍升高了100%。阿司匹林可减少胶原诱导的血小板聚集，从而抑制血小板微栓子的形成，而不影响凝血因子。阿司匹林的这种作用被认为是导致阿司匹林组输血后升高的PVR降至休克前值的原因。由于与休克状态相关的代谢性酸中毒，在给休克患者输血时建议同时给予碳酸氢钠。对阿司匹林在休克患者早期治疗以及高危情况下预防方面进行临床试验是合理的。
