Baraldi P G, Cacciari B, Guiotto A, Romagnoli R, Spalluto G, Leoni A, Bianchi N, Feriotto G, Rutigliano C, Mischiati C, Gambari R
Dipartimento di Scienze Farmaceutiche, Università di Ferrara, Italy.
Nucleosides Nucleotides Nucleic Acids. 2000 Aug;19(8):1219-29. doi: 10.1080/15257770008033045.
We designed and synthesized the hybrid 6, prepared combining the minor groove binders distamycin A and pyrrolo [2,1-c][1,4] benzodiazepine (PBD) 4, related to the natural occurring anthramycin (2) and DC-81 (3). In this paper, the effects of the compound 6 on molecular interactions between DNA and transcription factor Sp1 were studied. The results obtained demonstrate that PBD-distamycin hybrid is a powerful inhibitor of Sp1/DNA interactions.
我们设计并合成了杂合物6，它是由与天然存在的氨茴霉素（2）和DC - 81（3）相关的小沟结合剂放线菌素A和吡咯并[2,1 - c][1,4]苯并二氮杂䓬（PBD）4组合而成。本文研究了化合物6对DNA与转录因子Sp1之间分子相互作用的影响。所得结果表明，PBD - 放线菌素杂合物是Sp1/DNA相互作用的强效抑制剂。
