Bonora G M, De Franco A M, Rossin R, Veronese F M, Ferruti P, Plyasunova O, Vorobjev P E, Pyshnyi D V, Komarova N I, Zarytova V F
Dept. of Chemical Sciences, University of Trieste, Italy.
Nucleosides Nucleotides Nucleic Acids. 2000 Aug;19(8):1281-8. doi: 10.1080/15257770008033051.
A new amphiphilic, high-molecular weight poly (N-acryloylmorpholine) (PAcM) polymer has been used to be linked to oligonucleotide chains through a liquid-phase stepwise synthesis. This new conjugate has been investigated for its melting property, nuclease stability and capacity to elicit RNase H activity. Its antisense activity against an HIV-1 target has been also evaluated.
一种新型两亲性高分子量聚（N-丙烯酰基吗啉）（PAcM）聚合物已通过液相逐步合成法与寡核苷酸链相连。对这种新型缀合物的熔解特性、核酸酶稳定性以及引发RNase H活性的能力进行了研究。还评估了其针对HIV-1靶点的反义活性。
