液晶分散体中的双链核酸作为交联超分子结构的构建单元。

Double-stranded nucleic acids in liquid-crystalline dispersions as building blocks for cross-linked supramolecular structures.

作者信息

Yevdokimov Y M, Salyanov V I, Mchedlischvili B V, Bykov V A, Belyaev A V, Saunin S A, Spener F, Palumbo M

机构信息

VA Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences, Moscow.

出版信息

Nucleosides Nucleotides Nucleic Acids. 2000 Aug;19(8):1355-64. doi: 10.1080/15257770008033057.

DOI:10.1080/15257770008033057

PMID:11097064

Abstract

Double-stranded DNA fixed in a cholesteric liquid-crystalline dispersion was used for generating an ordered supramolecular structure in the presence of anthracycline and copper (II) ions. The structure is stable in a water-salt solution and does not require poly(ethyleneglycol).The ordered network can be immobilized on the surface of a polymeric film, and may collapse in the presence of biologically and pharmacologically relevant compounds. Accordingly, the DNA-based liquid-crystalline network represents the basis to obtain novel highly sensitive biosensing units.

摘要

固定在胆甾型液晶分散体中的双链DNA用于在蒽环类药物和铜（II）离子存在的情况下生成有序的超分子结构。该结构在水盐溶液中稳定，且不需要聚乙二醇。有序网络可以固定在聚合物膜表面，并且在存在生物学和药理学相关化合物时可能会塌陷。因此，基于DNA的液晶网络是获得新型高灵敏度生物传感单元的基础。