Evdokimov Iu M, Salianov V I, Skuridin S G, Badaev N S
Mol Biol (Mosk). 1995 Jan-Feb;29(1):180-91.
The X-ray and optical properties as well as the textures of liquid crystals formed of DNA molecules bound in complex with an anthracycline antibiotic daunomycin were investigated. It was shown that DNA.daunomycin complexes, depending on the extent of alteration of the DNA secondary structure by daunomycin, could yield two types of cholesterics differing in the direction of their spatial twisting as well as nematics. Liquid-crystalline dispersions of DNA.daunomycin complexes have CD spectra with "mirror" bands depending on daunomycin concentration. "Testing" of the orientation of daunomycin molecules on the DNA in liquid-crystalline particles suggested two types of binding.
研究了与蒽环类抗生素柔红霉素复合结合的DNA分子所形成液晶的X射线、光学性质以及织构。结果表明，DNA-柔红霉素复合物根据柔红霉素对DNA二级结构的改变程度，可产生两种空间扭曲方向不同的胆甾相以及向列相。DNA-柔红霉素复合物的液晶分散体具有取决于柔红霉素浓度的带有“镜像”带的圆二色光谱。对液晶颗粒中DNA上柔红霉素分子取向的“测试”表明存在两种结合类型。
