Wollstein G, Garway-Heath D F, Poinoosawmy D, Hitchings R A
Glaucoma Unit, Moorfields Eye Hospital, City Road, London, UK.
Ophthalmology. 2000 Dec;107(12):2267-71. doi: 10.1016/s0161-6420(00)00352-3.
To evaluate the optic disc for structural abnormalities in the contralateral eye of unilateral normal pressure glaucoma patients.
Cross-sectional study.
Fifty-three unilateral normal pressure glaucoma patients.
Optic disc imaging with the Heidelberg Retina Tomograph (HRT).
Optic disc structural parameters.
Of the contralateral (normal visual field) eyes, 79.2% were found to have an abnormal optic disc by HRT analysis. Of the glaucomatous (abnormal visual field) eyes, 94.3% were found to have an abnormal disc. The patterns of disc abnormality were defined as marked or moderate diffuse thinning of the neuroretinal rim (NRR) or broad or narrow focal thinning of the NRR. The most common pattern in the contralateral eyes was moderate diffuse thinning of the NRR (45.2%). The most frequently abnormal segments were the nasal superior (73. 8%) followed by the nasal inferior and the global NRR parameter (both 54.8%).
A high frequency of NRR thinning was found in the contralateral (normal visual field) eyes of unilateral normal pressure glaucoma patients by HRT analysis. Knowing whether these abnormalities predict future progression to the development of visual field abnormality must wait until longitudinal studies are completed. If a disc abnormality is shown to predict future field loss, then early identification will allow early treatment.
评估单侧正常眼压性青光眼患者对侧眼视盘的结构异常情况。
横断面研究。
53名单侧正常眼压性青光眼患者。
使用海德堡视网膜断层扫描仪（HRT）对视盘进行成像。
视盘结构参数。
通过HRT分析发现，在对侧（视野正常）眼中，79.2%存在视盘异常。在青光眼（视野异常）眼中，94.3%存在视盘异常。视盘异常模式定义为神经视网膜 rim（NRR）明显或中度弥漫性变薄，或NRR广泛或局限性狭窄变薄。对侧眼中最常见的模式是NRR中度弥漫性变薄（45.2%）。最常出现异常的节段是鼻上（73.8%），其次是鼻下和整体NRR参数（均为54.8%）。
通过HRT分析发现，单侧正常眼压性青光眼患者的对侧（视野正常）眼中NRR变薄的频率较高。要确定这些异常是否能预测未来视野异常的发展，必须等待纵向研究完成。如果视盘异常被证明可预测未来的视野缺损，那么早期识别将有助于早期治疗。
