用于胃肠道疾病口服细菌疗法和细菌预防的芽孢杆菌属的特性
Characterization of Bacillus species used for oral bacteriotherapy and bacterioprophylaxis of gastrointestinal disorders.
作者信息
Hoa N T, Baccigalupi L, Huxham A, Smertenko A, Van P H, Ammendola S, Ricca E, Cutting A S
机构信息
School of Biological Sciences, Royal Holloway University of London, Egham, Surrey TW20 0EX, United Kingdom.
出版信息
Appl Environ Microbiol. 2000 Dec;66(12):5241-7. doi: 10.1128/AEM.66.12.5241-5247.2000.
Abstract
Bacillus subtilis spores are being used for oral bacteriotherapy and bacterioprophylaxis of gastrointestinal disorders in both humans and animals. Since B. subtilis is an aerobic saprophyte, how spores may benefit the gut microbiota is an intriguing question, since other probiotics such as Lactobacillus spp. which colonize the gut are anerobes. As a first step in understanding the potential effects of ingesting spores, we have characterized five commercial products. An extensive biochemical, physiological, and phylogenetic analysis has revealed that four of these products are mislabeled. Moreover, four of these products showed high levels of antibiotic resistance.
摘要
枯草芽孢杆菌孢子正被用于人类和动物胃肠道疾病的口服细菌疗法和细菌预防。由于枯草芽孢杆菌是一种需氧腐生菌，孢子如何有益于肠道微生物群是一个有趣的问题，因为其他定殖于肠道的益生菌如乳酸杆菌属是厌氧菌。作为了解摄入孢子潜在影响的第一步，我们对五种商业产品进行了表征。广泛的生化、生理和系统发育分析表明，其中四种产品标签有误。此外，这些产品中有四种显示出高水平的抗生素抗性。
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