Behre H M, Kuhlage J, Gassner C, Sonntag B, Schem C, Schneider H P, Nieschlag E
Assisted Reproduction Unit, Department of Obstetrics and Gynaecology, University of Münster, Germany.
Hum Reprod. 2000 Dec;15(12):2478-82. doi: 10.1093/humrep/15.12.2478.
The timing of sexual intercourse in relation to ovulation strongly influences the chance of conception. Daily serum LH measurements or transvaginal ultrasonography are not practical to determine ovulation in consecutive cycles for an individual. A prospective study was initiated to test the home use performance of the ClearPlan Fertility Monitor (CPFM) in ovulation prediction compared with transvaginal ultrasonography and serum hormone measurements. A total of 53 women aged 18-39 years with a normal uterus and at least one ovary, cycle length between 21-42 days and not using medication which interferes with ovarian function contributed 150 cycles for analysis. One cycle was anovulatory and no LH surge, indicating peak fertility, was detected by the monitor. Of the remaining 149 cycles, 135 (90.6%) had a monitor LH surge and ultrasonographically confirmed ovulation. Ovulation was detected in 91.1% of cycles during the 2 days of CPFM peak fertility. Ovulation was observed in 51.1% of cycles 1 day and in 43.2% of cycles 2 days after the surge in serum LH. Ovulation never occurred before CPFM peak fertility or the serum LH surge day. CPFM can help women who desire pregnancy to time intercourse. It may also have potential as a diagnostic aid and for monitoring the treatment of infertility.
性交时间与排卵的关系对受孕几率有很大影响。对于个体而言，每日检测血清促黄体生成素（LH）或经阴道超声检查来确定连续周期的排卵情况并不实用。一项前瞻性研究启动，旨在测试ClearPlan生育监测仪（CPFM）在排卵预测方面的家庭使用性能，并与经阴道超声检查和血清激素测量进行比较。共有53名年龄在18至39岁之间、子宫正常且至少有一个卵巢、月经周期长度在21至42天之间且未使用干扰卵巢功能药物的女性贡献了150个周期用于分析。其中一个周期无排卵，监测仪未检测到促黄体生成素峰值（即生育高峰）。在其余149个周期中，135个（90.6%）出现了监测仪促黄体生成素峰值且经超声检查确认排卵。在CPFM生育高峰的2天内，91.1%的周期检测到排卵。在血清促黄体生成素峰值出现后的1天，51.1%的周期观察到排卵；在血清促黄体生成素峰值出现后的2天，43.2%的周期观察到排卵。排卵从未发生在CPFM生育高峰或血清促黄体生成素峰值日之前。CPFM可以帮助希望怀孕的女性把握性交时间。它还可能具有作为诊断辅助手段以及监测不孕症治疗的潜力。
