Tang Y Q, Sattler I, Thiericke R, Grabley S, Feng X Z
Hans-Knöll-Institut für Naturstoff-Forschung e.V., Jena, Germany.
J Antibiot (Tokyo). 2000 Sep;53(9):934-43. doi: 10.7164/antibiotics.53.934.
Four new lactone compounds, named feigrisolides A to D (1 to 4), have been isolated from Streptomyces griseus. The chemical structures were determined by detail analysis of their spectroscopic data and chemical transformations. Structurally, the feigrisolides A (1) and B (2) are hepta-lactones, feigrisolide C (3) and D (4) are 16-membered macrodiolides. Biological studies showed that feigrisolide B (2) exhibited strong antibacterial, as well as medium cyctotoxic, and antiviral activities. Feigrisolides A (1), C (3) and D (4) are medium inhibitors of 3alpha-hydroxysteroid-dehydrogenase (3alpha-HSD) inhibiting activity.
从灰色链霉菌中分离出了四种新的内酯化合物，命名为费氏内酯A至D（1至4）。通过对其光谱数据和化学转化的详细分析确定了化学结构。在结构上，费氏内酯A（1）和B（2）是七元内酯，费氏内酯C（3）和D（4）是16元大环二醇内酯。生物学研究表明，费氏内酯B（2）具有很强的抗菌活性，以及中等程度的细胞毒性和抗病毒活性。费氏内酯A（1）、C（3）和D（4）是3α-羟基类固醇脱氢酶（3α-HSD）抑制活性的中等抑制剂。
