Kwon O S, Park S H, Yun B S, Pyun Y R, Kim C J
Korea Research Institute of Bioscience and Biotechnology, Yusong, Taejon.
J Antibiot (Tokyo). 2000 Sep;53(9):954-8. doi: 10.7164/antibiotics.53.954.
A diketopiperazine (1) has been isolated from the culture broth of Penicillium sp. F70614 and its structure has been determined to be cyclo(dehydroala-L-Leu) by various spectroscopic analyses. This compound selectively inhibited yeast alpha-glucosidase and porcine intestinal alpha-glucosidase with IC50 values of 35 and 50 microg/ml, respectively. However, it did not show significant inhibitory effects against almond beta3-glucosidase, Aspergillus alpha-galactosidase, Escherichia coli beta-galactosidase and jack bean alpha-mannosidase.
