Huang Huarong, Liu Ting, Wu Xiaoen, Guo Junxi, Lan Xiong, Zhu Qin, Zheng Xi, Zhang Kun
a School of Chemical Engineering and Light Industry , Guangdong University of Technology , Guangzhou , China.
Nat Prod Res. 2017 Nov;31(22):2593-2598. doi: 10.1080/14786419.2017.1283498. Epub 2017 Feb 1.
One new chromone derivative, (2'S*)-2-(2'-hydroxypropyl)-5-methyl-7, 8-dihydroxy-chromone (1), together with three known compounds, bacillisporin A (2), bacillisporin B (3) and 5-carboxyphthalide (4) were obtained from the mangrove-derived fungus Penicillium aculeatum (No. 9EB). Their structures were elucidated by the detailed analysis of comprehensive spectroscopic data. Compounds 2 and 3 exhibited potent inhibitory activity against Bacillus subtilis with the same MIC values of 0.13 ± 0.02 μM, whereas compound 1 showed antibacterial activity against Salmonell with an MIC value of 2.00 ± 0.02 μM. Compound 2 and 3 possessed significant inhibitory activity against α-glucosidase with IC values of 33.55 ± 0.63 and 95.81 ± 1.12 μM, respectively.
从来源于红树林的棘孢青霉（编号9EB）中得到了一种新的色酮衍生物，(2'S*)-2-(2'-羟丙基)-5-甲基-7,8-二羟基色酮（1），以及三种已知化合物，芽孢杆菌素A（2）、芽孢杆菌素B（3）和5-羧基苯酞（4）。通过对综合光谱数据的详细分析确定了它们的结构。化合物2和3对枯草芽孢杆菌表现出强效抑制活性，最小抑菌浓度（MIC）值相同，均为0.13±0.02μM，而化合物1对沙门氏菌显示出抗菌活性，MIC值为2.00±0.02μM。化合物2和3对α-葡萄糖苷酶具有显著抑制活性，IC值分别为33.55±0.63和95.81±1.12μM。
