Kesserü E, Camacho-Ortega P, Laudahn G, Schopflin G
Fertil Steril. 1975 Jan;26(1):57-61. doi: 10.1016/s0015-0282(16)40875-7.
The presence of progestogens in the cervical mucus suppresses and arrests sperm penetration. Using the Kremer technique, the effects of in vitro released progesterone, d-norgestrel, and cyproterone acetate were studied by inserting silicone rubber threads bearing the respective compounds into capillary tubes containing cervical mucus. Control tubes were fitted with nonmedicated silicone rubber threads. After 24 hours of incubation, the sperm migration test was carried out to evaluate penetration depth, qualitative motility, and proportion of motile forms. Progesterone produced the greatest alterations. Migration was arrested within 30 minutes, the distance reached was consistently less than 2 cm, and sperm were completely immobile at 24 hours. D-norgestrel also exhibited a distinct spermiostatic effect, but it was not as intense as that of progesterone. Cyproterone acetate was practically effective during the first 120 minutes and produced alterations only in the qualitative and proportional motility.
宫颈黏液中孕激素的存在会抑制并阻止精子穿透。采用克雷默技术，通过将含有相应化合物的硅橡胶线插入装有宫颈黏液的毛细管中，研究了体外释放的孕酮、炔诺孕酮和醋酸环丙孕酮的作用。对照管装有不含药物的硅橡胶线。孵育24小时后，进行精子迁移试验以评估穿透深度、定性活力和活动形态比例。孕酮产生的变化最大。迁移在30分钟内被阻止，到达的距离始终小于2厘米，并且在24小时时精子完全不活动。炔诺孕酮也表现出明显的杀精作用，但不如孕酮强烈。醋酸环丙孕酮在前120分钟内实际有效，并且仅在定性和比例活力方面产生变化。
