Lee W I, Blandau R J
Fertil Steril. 1979 Sep;32(3):320-3.
It is known that progestins can induce in the secretory cells of the cervix the excretion of a mucus that is highly viscuos, scanty, and impenetrable to spermatozoa. Mucus of this type is similar to that excreted during the luteal phase of the normal human menstrual cycle and the cow estrous cycle. It is a natural sequence to ask the question, do progestins also have a direct effect on sperm motility? With dynamic laser light-scattering we measured the motility of freshly washed human spermatozoa and of spermatozoa in the presence of a progesterone, both in terms of their swimming speed distribution as expressed in the spectrum of scattered light. The swimming speed was significantly reduced when the concentration of progesterone was three orders of magnitude greater than that of the physiologic level. This finding confirms the finding in earlier biochemical studies that progesterone has a distinct spermiostatic effect. We suggest this answer to the above question: progestin-releasing contraceptive devices may act on spermatozoa directly as well as in the secretory cells of the cervix.
已知孕激素可促使子宫颈分泌细胞排出一种高度黏稠、量少且精子无法穿透的黏液。这种类型的黏液类似于正常人类月经周期黄体期和母牛发情周期所分泌的黏液。自然而然会提出这样一个问题：孕激素对精子活力是否也有直接影响？我们使用动态激光散射技术，测量了刚洗涤过的人类精子以及在存在孕酮情况下精子的活力，这两种情况都是根据散射光谱中所表达的游动速度分布来测量的。当孕酮浓度比生理水平高三个数量级时，精子游动速度显著降低。这一发现证实了早期生化研究中的发现，即孕酮具有明显的抑制精子作用。我们对上述问题给出如下答案：释放孕激素的避孕装置可能直接作用于精子，也可能作用于子宫颈的分泌细胞。
