Bentourkia M, Bol A, Ivanoiu A, Labar D, Sibomana M, Coppens A, Michel C, Cosnard G, De Volder A G
Positron Tomography Laboratory, University of Louvain, 2 Chemin du Cyclotron, B-1348, Louvain-la-Neuve, Belgium.
J Neurol Sci. 2000 Dec 1;181(1-2):19-28. doi: 10.1016/s0022-510x(00)00396-8.
The regional cerebral blood flow (rCBF) and metabolic rate for glucose (rCMRGlc) are associated with functional activity of the neural cells. The present work reports a comparison study between rCBF and rCMRGlc in a normal population as a function of age. 10 young (25.9+/-5.6 years) and 10 old (65.4+/-6.1 years) volunteers were similarly studied at rest. In each subject, rCBF and rCMRGlc were measured in sequence, during the same session. Both rCBF and rCMRGlc values were found to decrease from young (mean rCBF=43.7 ml/100 g per min; mean rCMRGlc=40.6 micromol/100 g per min) to old age (mean rCBF=37.3 ml/100 g per min; mean rCMRGlc=35.2 micromol/100 g per min), resulting in a drop over 40 years of 14.8% (0.37%/year) and 13.3% (0.34%/year), respectively. On a regional basis, the frontal and the visual cortices were observed to have, respectively, the highest and the lowest reduction in rCBF, while, for rCMRGlc, these extremes were observed in striatum and cerebellum. Despite these differences, the ratio of rCBF to rCMRGlc was found to have a similar behavior in all brain regions for young and old subjects as shown by a correlation coefficient of 88%. This comparative study indicates a decline in rCBF and rCMRGlc values and a coupling between CBF and CMRGlc as a function of age.
局部脑血流量（rCBF）和葡萄糖代谢率（rCMRGlc）与神经细胞的功能活动相关。本研究报告了正常人群中rCBF和rCMRGlc随年龄变化的比较研究。10名年轻志愿者（25.9±5.6岁）和10名老年志愿者（65.4±6.1岁）在静息状态下接受了类似的研究。在每个受试者中，在同一次检查期间依次测量rCBF和rCMRGlc。结果发现，rCBF和rCMRGlc值均从年轻时（平均rCBF = 43.7 ml/100g每分钟；平均rCMRGlc = 40.6 μmol/100g每分钟）下降到老年时（平均rCBF = 37.3 ml/100g每分钟；平均rCMRGlc = 35.2 μmol/100g每分钟），40年内分别下降了14.8%（每年0.37%）和13.3%（每年0.34%）。在区域基础上，观察到额叶和视觉皮层的rCBF减少最多和最少，而对于rCMRGlc，纹状体和小脑的减少最为极端。尽管存在这些差异，但年轻和老年受试者在所有脑区中rCBF与rCMRGlc的比值表现相似，相关系数为88%。这项比较研究表明，rCBF和rCMRGlc值随年龄下降，并且CBF和CMRGlc之间存在耦合关系。
