Manabe Y C, Bishai W R
Johns Hopkins University, Departments of Medicine and International Health, Baltimore, Maryland 21205, USA.
Nat Med. 2000 Dec;6(12):1327-9. doi: 10.1038/82139.
Mycobacterium tuberculosis is a globally successful pathogen due to its ability to persist for long periods of time unrecognized by the human immune system. The panoply of genes that allows the organism to enter latency and then re-emerge later during endogenous reinfection are now being elucidated. Novel antimicrobials and vaccines will need to target these mycobacterial pathogenic mechanisms to suceed against tuberculosis.
结核分枝杆菌是一种在全球范围内成功的病原体，因为它能够长时间潜伏而不被人体免疫系统识别。现在，使得该生物体进入潜伏状态并在内源性再感染期间后期再次出现的一系列基因正在被阐明。新型抗菌药物和疫苗需要针对这些分枝杆菌致病机制，才能成功对抗结核病。
