Division of Genetics, Wadsworth Center, New York State Department of Health, Albany, NY 12208, USA.
Division of Translational Medicine, Wadsworth Center, New York State Department of Health, Albany, NY 12208, USA.
Microbiology (Reading). 2021 Feb;167(2). doi: 10.1099/mic.0.001035.
Treatment of tuberculosis requires a multi-drug regimen administered for at least 6 months. The long-term chemotherapy is attributed in part to a minor subpopulation of nonreplicating cells that exhibit phenotypic tolerance to antibiotics. The origins of these cells in infected hosts remain unclear. Here we discuss some recent evidence supporting the hypothesis that hibernation of ribosomes in induced by zinc starvation, could be one of the primary mechanisms driving the development of nonreplicating persisters in hosts. We further analyse inconsistencies in previously reported studies to clarify the molecular principles underlying mycobacterial ribosome hibernation.
结核病的治疗需要至少 6 个月的多药物治疗方案。这种长期的化疗部分归因于一小部分非复制细胞，这些细胞对抗生素表现出表型耐受。这些细胞在受感染宿主中的起源尚不清楚。在这里，我们讨论了一些支持这样一种假设的最新证据，即锌饥饿诱导的核糖体休眠可能是导致宿主中非复制持久存在的主要机制之一。我们进一步分析了以前报道的研究中的不一致之处，以阐明分枝杆菌核糖体休眠的分子原理。
