Bauduceau O, Berlioz A, Buisson Y
Service de Santé, de l'Institut Pasteur, Paris, France.
Med Trop (Mars). 2000;60(2):167-70.
A seroepidemiological study in army conscripts was carried out to collect data on hepatitis B, C, and E in New Caledonia. All young men recruited between October 1998 and June 1999 (n = 351) were retrospectively included in study. Anamnestic data was obtained during the induction physical examination. Blood tests to detect viral markers and assessment of liver function were performed in all cases. The incidence of hepatitis B was 6.6 p. 100 of chronic carriers of HB antigens. The overall number of vaccinated subjects was low, i.e., 17.9 p. 100. The incidence of carriers presenting at least anti-HBc antibodies was higher in persons of Melanesian and Wallisian extraction, i.e. 59.5 p. 100 and 49.2 p. 100 respectively. This is logical since vaccination rates in these ethnic groups were lower. The incidence was also higher in the northern province and islands, i.e., 48.7 p. 100 and 75 p. 100. Mention of a family history of hepatitis B was a significant predictor of infection. No case of hepatitis C was found. Six carriers of anti-HVE were identified including three who had never left New Caledonia. Detection tests for viral RNA were negative in all cases. This study confirms the high incidence of hepatitis B in New Caledonia and the need for mass vaccination. Findings also suggest that the area may still be free of hepatitis C but the presence of hepatitis E cannot be ruled out.
在新喀里多尼亚的应征入伍士兵中开展了一项血清流行病学研究,以收集有关乙型、丙型和戊型肝炎的数据。1998年10月至1999年6月招募的所有年轻男性(n = 351)均被回顾性纳入研究。在入伍体检期间获取既往病史数据。所有病例均进行了检测病毒标志物的血液检查和肝功能评估。乙型肝炎的发病率为每100名HB抗原慢性携带者中有6.6例。接种疫苗的受试者总数较低,即每100人中有17.9例。出现至少抗-HBc抗体的携带者发病率在美拉尼西亚人和瓦利斯群岛人后裔中较高,分别为每100人中有59.5例和49.2例。这是合乎逻辑的,因为这些族裔群体的疫苗接种率较低。北部省份和岛屿的发病率也较高,分别为每100人中有48.7例和75例。提及有乙型肝炎家族史是感染的一个重要预测因素。未发现丙型肝炎病例。鉴定出6例抗-HVE携带者,其中3例从未离开过新喀里多尼亚。所有病例的病毒RNA检测均为阴性。本研究证实了新喀里多尼亚乙型肝炎的高发病率以及大规模接种疫苗的必要性。研究结果还表明,该地区可能仍无丙型肝炎,但不能排除戊型肝炎的存在。